Lewisburg is a village in Preble County, Ohio, United States, founded in 1818. The current village incorporates two prior villages, the original …Lewisburg is a village in Preble County, Ohio, United States, founded in 1818. The current village incorporates two prior villages, the original Lewisburg and Euphemia, which merged in 1916. The population was 1,745 at the 2020 census. It is part of the Dayton Metropolitan Statistical Area.