Nicosia is a comune in the province of Enna, in the Italian region of Sicily. It is located at 720 metres above sea level, on a rocky massive culmiā¦Nicosia is a comune in the province of Enna, in the Italian region of Sicily. It is located at 720 metres above sea level, on a rocky massive culminating in four imposing hills. The origin of Nicosia is uncertain. Nicosia and Troina are the northernmost towns in the province of Enna. The vicinity was traditionally made up of salt mines and arable lands.