Lake Monroe is one of the lakes that make up the St. Johns River system. The port city of Sanford is situated along the southern shore, while DeBary and Deltona are located along the northern shore. Two major central Florida roadways that run near the lake are State Road 415 and Interstate 4. It forms the border of Seminole County and Volusia County It is th…Lake Monroe is one of the lakes that make up the St. Johns River system. The port city of Sanford is situated along the southern shore, while DeBary and Deltona are located along the northern shore. Two major central Florida roadways that run near the lake are State Road 415 and Interstate 4. It forms the border of Seminole County and Volusia County It is the 8th largest lake in the Orlando metropolitan area, after Lake Jesup, 7 miles to the south.
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