Making lineup decisions can be the most frustrating — or most rewarding — part of fantasy football. We’re to help you make those decisions with our fantasy start ’em/sit ’em picks. It’s only Week 4. Our opinions should shift based on what we’ve seen so far,

Today, though, we’re focusing on running back. We’ve put together a quick list of five running backs to target on the fantasy football waiver wire ahead of Week 4. There are other RBs out there, but these are Broncos Wire’s targets of the week at the position.

With two star receivers sidelined, San Francisco's Jauan Jennings stepped up in a big way on Sunday, sending his fantasy value soaring.