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New framework leverages 3D protein structures for systems-level analysis of cancer mutations
A study from Cornell researchers could enable a quantum leap forward in identifying and deciphering cancer-driving genetic mutations, the first step in developing effective therapeutics. Cells become ...
Protein molecules can have complicated structures that dictate their functions. Christoph Burgstedt/Science Photo Library via Getty Images Although the Nobel Prizes in physics and chemistry are ...
University of Chicago alum John Jumper was awarded a share of the 2024 Nobel Prize in Chemistry on Oct. 9 for developing an AI model that predicts the complex folded structures of proteins. The Royal ...
Receptor proteins, expressed on the cell surface or within the cell, bind to different signaling molecules, known as ligands, initiating cellular responses. Taste receptors, expressed in oral tissues, ...
The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...
Giving Structure to Language: Profluent’s AI Models Move toward Precise and Steerable Protein Design
The “ChatGPT moment” for biology proceeds to unfold as protein language models, or machine learning tools trained on large databases of protein sequences, work to decode the language of life with the ...
Protein engineering is a powerful biotechnological process that focuses on creating new enzymes or proteins and improving the functions of existing ones by manipulating their natural macromolecular ...
Proteins are among the most studied molecules in biology, yet new research shows they can still hold surprising secrets. Researchers have discovered previously undetected chemical bonds within ...
One of the hallmarks of Alzheimer's disease is the clumping of proteins called Tau, which form tangled fibrils in the brain.
Proteins need to fold into specific shapes to perform their functions in cells, but they occasionally misfold, which can prevent them from properly functioning and even lead to disease. A study by ...
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