Bipolar disorder is characterized by bouts of extreme mood, with episodes of mania occurring alongside periods of depression. For the first time, researchers have now isolated the genetic factors responsible for the mania component,

Kanye West has been candid about his mental health struggles and how his bipolar type-1 diagnosis has affected him. West, who goes by the name Ye, revealed in 2018 that he was diagnosed with bipolar disorder when he dropped his album Ye.

Genetic mapping reveals mania drives most inherited risk in bipolar disorder, identifying new gene regions and calcium channel pathways.