The complement system was described over 100 years ago, and it is well established that activation of this pathway accompanies the great majority of autoimmune and inflammatory diseases. In addition, ...

Effective inhibition of the complement system is needed to prevent the accelerated clearance of nanomaterials by complement cascade and inflammatory responses. Here we show that a fusion construct ...

IIT Kanpur scientists have unlocked the mystery behind the C5aR2 immune receptor's unique function. Using advanced cryo-EM, ...

A group of researchers led by Prof. Arun K. Shukla in the Department of Biological Sciences and Bioengineering at the Indian Institute of Technology Kanpur (IIT-K) has unraveled a previously unknown ...

IIT Kanpur researchers, led by Professor Arun K Shukla, used cryo-EM to uncover the molecular basis of the atypical immune receptor C5aR2. They revealed its unique structure and developed a molecule ...