When researchers measure the activity of thousands of genes at once, they face a paradox that has shaped computational biology for decades: far too many variables and far too few samples. A single DNA ...

Definition: A microarray is a small, flat substrate carrying an ordered grid of microscopic probe features, each containing a known biological molecule, that is used to measure many molecular targets ...

DNA microarrays can be easily interrogated with only the naked eye using a new electrostatic imaging technique developed in the laboratory of Jay Groves, a chemist with Berkeley Lab, UC Berkeley and ...

The human genome project was undertaken to determine the human DNA sequence and analyze variation among individuals. To make use of this information, tools were developed that could collect and ...

In the early 1990s, my colleagues and I at Stanford University began tinkering with an interesting weed, the small flowering mustard plant, Arabidopsis thaliana. We set out to study genes involved in ...

The research community's rapid acceptance of microarrays notwithstanding, technical challenges remain. Biochip developers continue to grapple with these issues while upgrading their offerings and ...