The customary approach to early-phase clinical trial design, where the focus is on identification of the maximum tolerated dose, is not always suitable for noncytotoxic or other targeted therapies.
Applicable Analysis and Discrete Mathematics, Vol. 10, No. 2 (October 2016), pp. 408-446 (39 pages) An associative Boolean tree is a plane rooted tree whose internal nodes are labelled by AND or OR ...
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