Evasion of cell death is a hallmark of cancer cells that enables them to overcome endogenous barriers to cancer development and to resist treatment. Insights into the many facets of cell death, ...

From foundational research to drug development, researchers depend on accurate and efficient techniques that measure molecular interactions and binding kinetics. Conventional ligand binding assays ...

Apoptosis, or programmed cell death, is a tightly regulated biological process necessary for normal tissue maintenance and development. However, aberrations in apoptotic signaling networks are ...

With the recent advances in genomics, combinatorial chemistry, and automation, drug discovery scientists working in pharmaceutical, biotechnology, and academic environments are faced with the ...

Although chimeric antigen receptor (CAR)-T therapy — where a patient’s T cells are engineered to fight cancer — works well against blood cancers in young people, that success drops dramatically for ...

Fragment-based drug discovery (FBDD) has gained widespread recognition as a valuable approach in the search for lead drug candidates in drug discovery programs. It is utilized in conjunction with ...

Measuring Enzyme Kinetic Parameters with the ITC Universal Enzyme Assay Method Enzymes are important in drug discovery and development since they constitute approximately one-half of all known drug ...

The properties of phospholipase C (PLC) partially purified from Catharanthus roseus transformed roots were analyzed using substrate lipids dispersed in phospholipid vesicles, phospholipid-detergent ...

Faster CSF alpha-synuclein seeding kinetics predicted cognitive decline in Parkinson's in multiple cohorts. GBA1-associated Parkinson's exhibited quicker seeding kinetics than sporadic Parkinson's ...