Surface model of SpCas9–reverse transcriptase–pegRNA–target DNA complex. The prime editor, composed of a SpCas9 and a reverse transcriptase, reverse transcribes template sequence in pegRNA, resulting ...
The CRISPR-based genome editing toolbox is packed with powerful refinements. The latest of these, prime editing (PE), was first reported in Nature in 2019 by David Liu’s group. Using a prime editing ...
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