Bayesian estimation and maximum likelihood methods represent two central paradigms in modern statistical inference. Bayesian estimation incorporates prior beliefs through Bayes’ theorem, updating ...

Although epistasis is an important phenomenon in the genetics and evolution of complex traits, epistatic effects are hard to estimate. The main problem is due to the overparameterized epistatic ...

In multiple change-point problems, different data segments often follow different distributions, for which the changes may occur in the mean, scale or the entire distribution from one segment to ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 19 (May 10, 2011), pp. 7860-7865 (6 pages) The substitution rate in a gene can provide valuable ...