This study provides a deep understanding of NET's transport mechanism, offering a crucial structural foundation for the development of novel peptide-based drugs targeting the MATs family.

They work via serotonin and norepinephrine, so they have a dual mechanism of action. Examples are venlafaxine (Effexor), desvenlafaxine (Pristiq), duloxetine (Cymbalta), and milnacipran (Savella).

A NUMBER of sympathomimetic amines chemically related to norepinephrine (Fig. 1), which have either a catechol or β-hydroxyl group, can be stored in the vesicles of sympathetic nerves1 ...

Antiviral COVID-19 treatments are effective against Omicron The researchers studied the sensitivity of Omicron and Delta to several antiviral treatments with different mechanisms of action.