Background: Nivolumab (nivo) 480 mg (Q4W) flat dose has already been assessed for safety compared to other drug dose regimens in clinical trials [1]. However, few data about melanoma patients treated ...

The recommended nivolumab dose for patients weighing 40 kg or more is 480 mg every 4 weeks or 240 mg every 2 weeks until disease recurrence or unacceptable toxicity for up to 1 year. For pediatric ...

Results: Of 166 and 163 pts randomized to 480 mg Q4W and 240 mg Q2W, 164 and 161 pts were treated, respectively. Median follow-up was 9.5 mo (480 mg Q4W) and 10.2 mo (240 mg Q2W). Baseline ...

There were 668 patients who were enrolled in the study who were randomly assigned to either receive 1-mg/kg nivolumab plus 3-mg/kg ipilimumab with 480-mg nivolumab every 4 weeks for up to 2 years ...

They made the shared decision to proceed with nivolumab, 480 mg every 4 weeks with additional standard medications. After initiation of nivolumab, ...

Those in the treatment arm received 1 mg/kg intravenous (IV) nivolumab with 3 mg/kg IV ipilimumab every 3 weeks for up to four doses, followed by single-agent IV nivolumab at 480 mg every 4 weeks.

Nivolumab (3 mg per kilogram of body weight) and ipilimumab (1 mg per kilogram) were administered once every 3 weeks for four cycles. Patients then received nivolumab maintenance therapy (480 mg ...

In the first-line setting, the combination therapy demonstrated a significant improvement in PFS compared with chemotherapy, with median PFS not reached vs 5.8 months, respectively (HR, 0.21; P ...