so a conventional target-driven approach to CNS drug discovery has really not worked out well,” said Leahy. Instead, PsychoGenics has taken a phenotypic approach. “What better route to ...

The power of phenotypic screening was illustrated by a 2011 paper in Nature Reviews Drug Discovery that analysed how new medicines were discovered from 1999 to 2008 1.Over the period, target-based ...

We combine iPSC-derived models with our expertise in a wide range of phenotypic readouts. For example, for clients working in epilepsy drug discovery we have developed an iPSC-derived ...

Researchers at the University of Oklahoma have developed a breakthrough method of adding a single nitrogen atom to molecules, ...

High content imaging and analysis for drug discovery: phenotypic assays, instrumentation and software High content imaging and analysis offers a robust, high throughput analysis of large numbers of ...

Scientists engaged in drug discovery and development research generate vast quantities of data, particularly from cell-based preclinical models. When using cutting-edge imaging and omics technologies, ...

to refine cohorts based on specific phenotypic features. "GeneDx's database is a powerful resource that can help drive the future of drug discovery, unlocking critical tools for target validation ...

Early stage drug discovery has still not benefited from ... as well as more complex target product profiles guided by high content phenotypic data. In addition to its work with GSK and Sanofi ...

Ovation launches a GLP-1 dataset with WGS enabling biomaker discovery to advance precision medicine in metabolic diseases.