G protein-coupled receptors (GPCRs) constitute one of the largest families of membrane proteins and play a pivotal role in translating extracellular signals into diverse intracellular responses. A key ...

Intrigued by the properties of ion channel proteins commonly observed in cells, researchers have developed the first synthetic mechanosensitive potassium channel using a newly developed aromatic ...

A single mutation in a gene, Kcnc3, which encodes a potassium channel in neurons, causes learning deficits in mice, UT Southwestern researchers report in a new study in PNAS. The novel mutation ...

Scientists have identified the role of an ion channel that plays a key part in how cells break down and recycle components, a discovery that could open the door to new treatment strategies for ...

A group from The Mount Sinai Hospital / Mount Sinai School of Medicine have identified and characterized a novel a GIRK1-selective activator, GiGA1 capable of selectively opening a subset of G-protein ...

Potassium channel blockers are a type of medication used to treat conditions like cardiac arrhythmias. They block the movement of potassium channels in the body, disrupting the body’s electrical ...

Researchers decipher the function of an ion channel involved in cellular degradation processes and create new possibilities for Parkinson’s therapies.

Researchers have answered an important question in biology by discovering the exquisite mechanism by which channels in the cell membrane sense voltage changes that trigger them to snap open or slam ...