Figure 1: Ethanol potentiates a potassium current induced by rapid activation of GABA B receptors in cerebellar granule cells in culture. To assess ethanol effects on GIRKs coupled to different ...

G protein-coupled inwardly rectifying potassium channels (GIRK) are important for neuronal signaling and membrane excitability. In the present study, we intend to find whether GIRK channels express ...

Previous research has suggested that neurons in multiple sclerosis (MS) exhibit metabolic exhaustion, believed to be caused by chronic hyperexcitability, which can lead to neurodegeneration.

Ion selectivity is an important property of cell membrane ion channels. For example, potassium ion channels are more permeable to potassium ions than to sodium ions. The mechanism underlying the ready ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 11 (May 28, 2002), pp. 7774-7779 (6 pages) Andersen's syndrome, an autosomal dominant disorder related to ...

A recent study brings new insights to an area of ion channel regulation: whether voltage-gated potassium (Kv) channels can be regulated by physiological changes to PIP2. A recent study in the Journal ...

This is a preview. Log in through your library . Abstract HERG (human ether-a-go-go-related gene) encodes a delayed rectifier K+ channel vital to normal repolarization of cardiac action potentials.

Neurons transmit information with the help of special channels that allow the passage of potassium ions. Defective potassium channels play a role in epilepsy and depression. The scientists working ...

The underlying cause of multiple sclerosis, a disease that affects 2.5 million people worldwide, has proven elusive despite more than a century of research. Evidence indicates that multiple sclerosis ...

This article and associated images are based on a poster originally authored by Sivakumar, M, Smith, E, Shumate, J, Scampavia, L, Spicer, T, Hernandez, D and Peters, C and presented at ELRIG Drug ...