Taste, pain, or response to stress -- nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers have uncovered the ...

Researchers at Leipzig University and Martin Luther University Halle-Wittenberg have investigated a previously unknown process that occurs during protein synthesis in the cell. They examined how ...

A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role of astrocytic G protein-coupled receptors (GPCRs). This research offers ...

Researchers at Karolinska Institutet have identified two specific receptor proteins in the brain that, when activated, boost the organ’s built-in ability to break down the amyloid-beta plaques ...

Cancer immunotherapy, especially using T cells, is showing a lot of promise in treating blood cancers. Bioengineered T cells, especially those equipped with chimeric antigen receptors (CAR-T cells), ...

Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors. One in every three FDA-approved drugs targets a single ...

Two different versions of the mu-opioid receptor within a cellular membrane illustrate how the receptor changes its conformation to send a signal into the cell. Scientists captured six high-resolution ...

Kaplan-Meier methods estimated overall survival (OS) and duration of response (DOR). DOR was defined from the time of initial response to progression, death, or last follow-up. Median follow-up was ...

Scientists at École Polytechnique Fédérale Lausanne (EPFL), and at UNIL-CHUV, University Hospital Lausanne (CHUV) and University of Lausanne (UNIL) have developed a computational method to create ...