Methods for depth normalization have been assessed primarily with simulated data or cell-line–mixture data. There is a pressing need for benchmark data enabling a more realistic and objective ...

The challenges of deriving statistically robust conclusions from high-throughput technologies such as microarrays are well known. Yet the exploration of similar challenges for data from sequencers, ...

While conventional magnetic resonance imaging (MRI) is measured in arbitrary intensity units, much work has centered on the development of normalization procedures. In this talk, we propose a simple, ...