Research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) limits the expression of the gene Scn4b, regulating neuronal activity and ...

New therapies for multiple myeloma are dramatically improving prognosis and extending survival. Better disease control is prolonging remission and allowing patients to live without any sign of disease ...

If you're someone or know someone recovering from addiction, you've likely seen a relapse. The rug gets pulled out from under you, the other shoe drops, and old feelings of worry and fear come ...

Fred D. Lublin, MD, discusses evolving concepts in MS, including earlier high-efficacy therapy, unrecognized progression, and ...

Researchers identify PV neurons in the prefrontal cortex as the gatekeepers of drug addiction relapse, offering a new target for precision treatment.

Having a high novelty-seeking personality trait may raise the risk of relapse after alcohol withdrawal. This finding comes from new research published in the Journal of Psychiatric Research. Alcohol ...

Panelists discuss how progression independent of relapse activity (PIRA) represents a distinct pathological process involving smoldering inflammation and neurodegeneration that drives disability in ...

For many patients diagnosed with diffuse large B-cell lymphoma (DLBCL), the first step in treatment is a standard regimen of chemotherapy. This approach cures most patients, but research shows that ...

Disability progression independent of relapse activity (PIRA) -- sometimes referred to as silent progression -- is a key integrating concept in the contemporary view of multiple sclerosis (MS). "The ...