One of the most important bioprocessing advances in recent years has been the rise in levels of manufactured therapeutic proteins. Indeed, the overall average yield reported for commercial monoclonal ...

Best practices in upstream processing seek to maintain cell health and product quality during cell culture. “Each is irreversibly susceptible to its environment and deviations that result in loss in ...

Scientist - Tumor Biology, Department for Human and Animal Cell Lines, Leibniz Institute DSMZ (German Collection of microorganisms and cell cultures) In the last decades, the upstream processing in ...

Real-time and in-line accurate measuring of protein (monoclonal antibody, or mAb) concentration has been shown across a wide dynamic range (0–135 g/L) through the ...

Modern upstream bioprocessing relies on tighter control strategies as regulators and manufacturers push toward real-time decision making. Yet the inherent variability of living cell systems makes it ...

In this interview, Kevin Broadbelt of Thermo Fisher Scientific discusses the small molecule applications of process Raman spectroscopy. How do cell therapies differ in complexity compared to ...

Continuous bioprocessing has emerged as a transformative approach in modern biomanufacturing, where integrated upstream and downstream operations enable uninterrupted production of biotherapeutics.