Recombinant adeno-associated virus (AAV) vectors are predominantly nonintegrating, but rare genomic integration events have been associated with oncogenesis in neonatal murine models. Here we report a ...
This article is based on a poster originally authored by Anne J Hout, Nikki Claassen, Ilse H Wolters, Johanna FB Pagano, and Karthikeyan Devaraju. Stable expression in gene therapies with transposons, ...
A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-long terminal repeats (LTR) integrase (IN) ...
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