Drug addiction is a chronic, often relapsing disorder that affects millions of people worldwide. Despite successful treatment, many individuals struggle to maintain sobriety and may relapse.

Scientists identify the protein DeltaFosB as the "master switch" that rewires the brain's memory and reward circuits, driving chronic cocaine addiction and relapse.

Researchers identify PV neurons in the prefrontal cortex as the gatekeepers of drug addiction relapse, offering a new target for precision treatment.

When a cocaine addict relapses, it isn't a matter of personal failure—it's the biological result of their brain's rewiring, new research finds. Michigan State University scientists have found that ...

Relapse prevention is why most people seek treatment, and with opioid use disorders (OUDs), there’s about a 90 percent relapse rate. This article explains why and how specific sayings from self-help ...

Cocaine addiction isn’t simply a failure of willpower — it’s the result of lasting biological changes in the brain.

For years, addiction was seen as a matter of personal failure—a bad habit or a lack of discipline. People believed those who struggled with substance abuse could stop if they simply wanted to. But ...

In Philadelphia, over 1,170 people died of opioid overdoses in 2022, the last year for which complete data is available. More than 300 more died just over the bridge in Camden County. Research ...

A person's basic personality traits might help predict if they will start drinking again after alcohol withdrawal. A new study shows that people with a strong desire for new experiences are more ...

Addiction is one of the most intensely studied conditions in modern medicine, yet even with high‑resolution brain scans and genetic tools, scientists still cannot fully explain why some people get ...