The Cavaliers lost a physical Game 1 at home to the Indiana Pacers on Sunday night as All-Star point guard Darius Garland sat with a sprained big toe. They'll go into Tuesday's Game 2 facing the prospect of playing without All-Star center and Defensive Player of the Year Evan Mobley and forward De'Andre Hunter.

The Cavaliers are trailing 1-0 in the series after their Game 1 loss, and now they're dealing with several injuries heading into Game 2.

The Cavaliers remained relatively free of injuries to key players during the regular season. But now, it seems, pain has set in, and at the worst possible time.