We report on crystal structures of ternary Thermus thermophilus Argonaute (TtAgo) complexes with 5′-phosphorylated guide DNA and a series of DNA targets. These ternary complex structures of ...

We are exposed to ionizing radiation more often than we think: when we bathe in the sun, which emits UV rays, or when we get X-rayed. Even when we are travelling on an intercontinental flight, which ...

When a double strand break, or DSB -- the most severe form of DNA damage -- occurs, the repair pathway may insert or delete genes at the break site or potentially rearrange genes throughout the strand ...

Physicists from the University of Basel have developed a new method to examine the elasticity and binding properties of DNA molecules on a surface at extremely low temperatures. With a combination of ...

One of the hallmarks of DNA damage is the rapid spreading of phosphorylated histone H2A (γ-H2AX) around a DNA double-strand break (DSB). In the budding yeast Saccharomyces cerevisiae, nearly all H2A ...