The development of robust clinical trial methodologies increasingly relies on advanced statistical frameworks for model selection and the characterisation of dose–response relationships. With modern ...

Stylized curves that illustrate the linear, threshold, and hormetic dose-response models for carcinogens. The central pillar upon which toxicological assessments are built is the dose-response ...

This is a preview. Log in through your library . Abstract This paper introduces a dose-response model for toxic quantal response data based on hit theory applied to the dose unit as transformed by a ...

A dose-response curve is the graphical representation of a dose-response relationship, the magnitude of response of an organism from exposure to drugs and chemical interactors. Usually, dose is ...

There is a well-established link between time spent in nature and better human health. However, the precise mechanism underlying this connection has been unclear, which has meant limited guidance for ...

Objective To identify the optimal dose and type of physical activity to improve functional capacity and reduce adverse events in acutely hospitalised older adults. Design Systematic review and ...

A toxicologist describes how regulators came to adopt the linear no threshold (LNT) dose-response approach to ionizing radiation exposure in the 1950s, which was later generalized to chemical ...

“For if one drinks much from a bottle marked ‘poison,’ it’s almost certain to disagree with one sooner or later.” —Lewis Carroll, “Alice’s Adventures in Wonderland” In the early 16th century, a Swiss ...

This is a preview. Log in through your library . Abstract The advantages of a generalised logistic dose response model as compared to a linear model were demonstrated while following the inhibitory ...