AMP-activated protein kinase (AMPK) plays a central role in maintaining energy balance in cells, especially under energy stress. While upstream activation by the kinase LKB1 is well recognized, the ...

Nowadays, the prevalence of sedentary lifestyles and high-caloric diets leads to an imbalance between energy intake and spending. Hence, in the last decades, we have observed a significant rise in ...

Our findings demonstrate that SOX9 overexpression alleviates hepatic lipid accumulation in MASH by activating the AMPK pathway. These results highlight SOX9 as a promising therapeutic target for ...

This story is sponsored by Health Utah. For years, the mantra for weight loss has been simple: eat less, move more. But what if everything you've been told about shedding pounds is wrong? Dr. Whit ...

Calorie restriction (CR) is a dietary intervention that promotes various metabolic changes. CR-induced lithocholic acid (LCA) production has been associated with improved life expectancy and many ...