For thousands of Americans, opioids no longer relieve pain—they cause pain. Known as "opioid tolerance," patients eventually become desensitized to opioids and more sensitive to pain after years of ...

WASHINGTON — New studies reveal that a learned compensatory response can trigger "drug tolerance," a physiological process central to addiction. Drug tolerance makes people need more and more drug to ...

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems—prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same ...

Editor’s Note: This is Part 2 of a three-part series looking into the opioid epidemic across the U.S., rehabilitation options in Weld County and stories from people who have overcome or are currently ...

At the cellular level, pain and pain relief are caused by two different signaling pathways. But the two pathways aren't necessarily independent of one another, according to a study published by ...

This is another one of the basic questions I get regarding addiction. It seems that people think about physical addiction and psychological addiction as somehow separate processes. I think this ...

This is another one of the basic questions I get regarding addiction. It seems that people think about physical addiction and psychological addiction as somehow separate processes. I think this ...

Nick Padlo's addiction to alcohol and drugs didn't happen overnight. "I was using them as a tool to cope with depression and anxiety," says the recovered addict and founder of Sophros Recovery ...