Although genome-wide association studies (GWASs) have identified numerous loci associated with complex traits, imprecise modeling of the genetic relatedness within study samples may cause substantial ...
The data scientist’s goal is to simultaneously reduce bias and variance as much as possible in order to obtain as accurate model as is feasible. However, there is a tradeoff to be made when selecting ...
The Annals of Applied Statistics, Vol. 11, No. 4 (December 2017), pp. 2027-2051 (25 pages) Linear mixed models (LMMs) are among the most commonly used tools for genetic association studies. However, ...
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