For example, low-dose antiangiogenic therapy resulted in improved temozolomide delivery in an orthotopic glioma xenograft model, but high-dose antiangiogenic therapy decreased delivery compared to ...

Antiangiogenic therapy is based on the theory that blocking new blood vessel formation in tumors will stop or slow their growth. Currently, four molecular-targeted drugs are approved by the FDA ...

We propose that antiangiogenic therapy can similarly stabilize vulnerable 'rupture-prone' plaques by pruning and normalizing immature intraplaque vessels, preventing further intraplaque hemorrhage.

Tumor therapy has evolved significantly over recent decades, yet tumors continue to develop resistance to conventional ...

This review covers state-of-the-art antiangiogenic targets for brain tumor treatment and discusses future challenges.

Although antiangiogenic therapy may be combined with radiotherapy, results have been mixed, and the appropriate order of administration has not yet been determined.

The current era of research in antiangiogenic therapy for cancer began in earnest in 1971 with the publication of Folkman's imaginative hypothesis, 1 but 33 years would elapse before the first ...

H. Jack West, MD: At this point, I would say that there really is not a great understanding of a mechanism of action for how and why patients and their tumors become resistant to antiangiogenic ...

Immunosuppression underlies resistance to anti-angiogenic therapy Study identifies role of non-classical monocytes in blocking action of anti-cancer drugs Date: July 14, 2017 Source: ...

July 18th 2018EP. 3: Ramucirumab in Relapsed/Refractory NSCLC July 18th 2018EP. 4: The Phase 3 REVEL Trial in NSCLC July 18th 2018EP. 5: VEGF Inhibition in NSCLC July 18th 2018EP. 7: Future Use of ...

The editorial by Duda et al, entitled, “Biomarkers of Antiangiogenic Therapy: How Do We Move From Candidate Biomarkers to Valid Biomarkers?” (J Clin Oncol 10.1200/JCO.2009.24.8021) was published ...

Tumor growth parameters predict response to anti-angiogenic therapy in mice. Dec 21, 2017. Fat rats show why breast cancer may be more aggressive in patients with obesity. Aug 7, 2017.