Mitochondria are organelles with two well ... It contains the protein complexes from the electron transport chain, the ATP synthase and the adenine nucleotide translocator (ANT).

Here, using a broad set of in vivo and in vitro measurements using purified enzymes, we find that leucinostatin A, but not lefleuganan, specifically targets the mitochondrial ATP synthase, inhibiting ...

Muscle biopsy at the age of 10 years revealed completely undetectable ATP synthase activity with otherwise ... methods as described previously.12 The mitochondrial matrix enzyme citrate synthase ...

BACKGROUND: Circular RNAs derived from both nuclear and mitochondrial genomes are identified in animal cells.

In a study published in Nature, researchers report the successful in vitro reconstitution of meiotic DNA double-strand breaks ...

A research collaboration has found that besides regulating the fusion of mitochondria, Mitofusin 2 also ensures protein quality control. This discovery could open up new routes to treating ...

Researchers have identified the mitochondrial calcium uniporter as a critical protein in the strengthening of synaptic ...

A paper by scientists affiliated with the University of São Paulo highlights new discoveries regarding the mechanisms of oxidative phosphorylation involved in ATP production. Recent studies have ...

Mitochondria organelles came from primordial bacterial endosymbionts and still preserve distinct genes for important functions like making ATP. To speed the emerging therapeutic research into the ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...