Among the hundreds of thousands of chemical compounds produced by plants, some may hold the key to treating human ailments and diseases. But recreating these complex, naturally occurring molecules in ...

The field of drug discovery faces many time-honored ... ‘brute force’ high-throughput screening approaches,” said Palframan. “So, we're using AI today for small molecule discovery to help us make ...

Large language models may unlock a new and valuable type of research.

In zebrafish, ketamine causes changes a brain circuit involved in "giving up." That may help explain how the drug helps ...

With this model, researchers may be able to discover antibody drugs capable of targeting a wide range of infectious diseases.

Here, the authors report thiazolyl ketone inhibitors of cPLA2α starting from compound GK470 (AVX235), and the discovery of a more potent and selective lead, GK420 (AVX420), with significant ...

Together with his postdoc, Shiga, he chose African trypanosomes as a target and trypan red as the drug, and soon established ... Shortly before the discovery of compound 606, Uhlenhuth had adapted ...

QUANTRO’s proprietary time-resolved functional transcriptomic discovery platform accelerates target screening for complex indications ... breakthrough for QUANTRO and more broadly for drug discovery, ...

Finding new medicines has always been a long, expensive, and complicated process. Scientists need to identify the right targets in the body, test thousands of potential compounds, and spend years in ...