San Francisco 49ers running back Isaac Guerendo was carted off the field in the first quarter against the Arizona Cardinals.

The 49ers lost another running back Sunday. Isaac Guerendo was carted off the field with injuries to his left knee and ankle. The team ruled out his return today. Guerendo was injured on the team's ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 ...

The San Francisco 49ers entered Sunday's season finale against the Arizona Cardinals with a depleted roster. Quarterback Josh Dobbs took the reins in place ...