State and federal prosecutors have charged more than 320 people in the largest coordinated takedown of health care fraud schemes in Justice Department history that uncovered nearly $15 billion in false claims.

Matthew Galeotti, head of the justice department’s criminal division, called the operation “the beginning of a new era of aggressive prosecution and data driven prevention” of healthcare fraud.

U.S. officials say hundreds of medical professionals will face federal charges for alleged roles in various healthcare schemes that resulted in financial losses to the tune of billions.