What defines a healthy gut microbiome? | Gut
A wider perspective on gut health considers the absence of digestive complaints as a key indicator. Symptoms like bloating, gas, irregular bowel movements and discomfort may not always be linked to a specific disorder but can indicate suboptimal gut health ().Therefore, a healthy gut, by this definition, is not only ‘free from diagnosed diseases’ but …
Exploring the role of genetics, gut microbiota and blood …
Oct 14, 2024 — We have read with interest the article by Bonfils et al , which explores the impact of parental IBD on offspring risk using a large Danish cohort.1 Their findings underscore the significance of genetic predisposition and shared environmental factors, with maternal IBD diagnosis before childbirth showing the highest risk (adjusted HR 6.27) and a similar pattern observed with paternal IBD ...
Metabolic reprogramming by mutant GNAS creates an actionable …
Sep 25, 2024 — Results Induction of Gnas R201C —and resulting G (s) alpha signalling—leads to the emergence of a gene signature of gastric (pyloric type) metaplasia in pancreatic neoplastic epithelial cells. CRISPR screening identified the synthetic essentiality of glycolysis-related genes Gpi1 and Slc2a1 in Kras G12D;Gnas R201C co-expressing cells. Real-time metabolic analyses in Kras;Gnas cells and ...
Lamb CA, et al. Gut 2019;68 ...
Guidelines on the management of ascites in cirrhosis | Gut
The British Society of Gastroenterology in collaboration with British Association for the Study of the Liver has prepared this document. The aim of this guideline is to review and summarise the evidence that guides clinical diagnosis and management of ascites in patients with cirrhosis. Substantial advances have been made in this area since the …
The road to a world-unified approach to the management of ... - Gut
Objective During the last decade, the management of gastric intestinal metaplasia (GIM) has been addressed by several distinct international evidence-based guidelines. In this review, we aimed to synthesise these guidelines and provide clinicians with a global perspective of the current recommendations for managing patients with GIM, as well as highlight evidence gaps that need to be addressed ...
Unravelling lipidomic disruptions across multiple tissues in
Oct 1, 2024 — With great interest, we read the article by Lou et al ,1 who reported deviated gut microbiota in children with autism spectrum disorders (ASD). Recently, increasing studies have revealed abnormalities in extraneural tissues, particularly the gastrointestinal (GI) tract.2 Besides, the important role of lipids in the gut-brain axis of ASD is highlighted by their involvement in neurodevelopmental ...
Impact of margin thermal ablation after endoscopic mucosal …
Sep 30, 2024 — Background and aims The efficacy of colorectal endoscopic mucosal resection (EMR) is limited by recurrence and the necessity for conservative surveillance. Margin thermal ablation (MTA) after EMR has reduced the incidence of recurrence at the first surveillance colonoscopy at 6 months (SC1). Whether this effect is durable to second surveillance colonoscopy (SC2) is unknown.
Need for standardised approaches to human microbiome research …
Oct 1, 2024 — The role of the human microbiome in GI disease is an area of significant clinical and academic interest. The microbiome may well influence a number of GI diseases ranging from cancer,1 2 to IBD,3 4 to liver disease.5 6 One of the current challenges faced by microbiome researchers is the variance in terminology, methodological approaches and lack of consistency regarding outcomes. This is an ...
Treatment of type 2 diabetes with MASLD: new evidence for …
Oct 23, 2024 — Metabolic dysfunction-associated steatotic liver disease (MASLD), is closely linked to type 2 diabetes (T2D).1 2 This strong association is due to shared pathophysiological pathways, including insulin resistance, mitochondrial dysfunction, adipose tissue dysfunction, low-grade inflammation and dysbiosis.3 The coexistence of MASLD and T2D affects the prognosis of both diseases in a ...