Beta cell dysfunction results from inadequate glucose sensing to stimulate insulin secretion therefore elevated glucose concentrations prevail. Persistently elevated glucose …

Jul 1, 2020 · In this review we focus on several features of human β cell dysfunction and pathology in type 2 diabetes, as revealed by direct assessment of isolated islet traits and …

Aug 6, 2025 · Emerging evidence from human studies places pancreatic beta cell dysfunction at the centre of early type 2 diabetes pathogenesis. While insulin resistance is a hallmark of the …

Dec 1, 2004 · We propose that there are five stages in the progression of diabetes (Fig. 1), each of which is marked by important changes in β-cell mass, phenotype, and function. Although …

Apr 25, 2025 · Again, I’ll talk about potential causes of beta-cell dysfunction and particularly a diminished first-phase insulin response, and what can be done about it, in a later blog post.

Gordon Weir and colleagues 1 argue that decreased β-cell mass is a key cause of type 2 diabetes. We do not debate that the volume of pancreatic β-cells has a role in maintaining …

Jul 10, 2025 · In this article, we look at the role of beta cells, the impact of type 2 diabetes on insulin and beta cells, and how to prevent and manage the loss of beta cell function in type 2...

Both type 1 and type 2 diabetes may involve beta cell dysfunction or death, although perhaps for different reasons, and in different points in the disease process.

Jun 16, 2020 · In this review, we discuss the progression of T2D in the context of beta-cell failure and describe how C-peptide testing can be used to assess beta-cell function in primary care …

Jan 30, 2023 · Defects in the function and mass of β-cells play a significant role in the development and progression of diabetes. Increased β-cell deficiency and β-cell apoptosis are …