KRAS (Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus.

The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus.

Apr 4, 2024 · The most frequently mutated of these oncogenic driver genes, called KRAS, is associated with some of the most fatal cancer types: lung, pancreatic and colorectal cancers.

Nov 15, 2021 · As the most frequently mutated oncogene, Kirsten rat sarcoma viral oncogene homologue (KRAS) has attracted substantial attention. The understanding of KRAS is constantly being updated by numerous...

Jan 22, 2025 · What is a KRAS mutation? KRAS-positive lung cancer patient, Jennifer, shares what she would tell a newly diagnosed KRAS-lung cancer patient. Dr. Melissa Johnson discusses the past, present and future of treating KRAS-positive lung cancer. KRAS is an important biomarker in lung cancer.

Jan 15, 2025 · Recent studies provide new insights into signaling by mutant KRAS, inhibitors of which have provided modest benefits for patients.

KRAS is a small GTPase that is among the most commonly mutated oncogenes in cancer. Here, we discuss KRAS biology, therapeutic avenues to target it, and mechanisms of resistance that tumors employ in response to KRAS inhibition.

Oct 11, 2024 · KRAS is a gene involved in cell growth regulation and mutations in KRAS, particularly common in pancreatic cancer, lead to uncontrolled cell division and are a major target for emerging cancer therapies.

GTPase KRas (KRAS) is a signal transducer protein, which plays an important role in various cellular signalling events such as in regulation of cell proliferation. It is a critical hub in the cell circuitry, as upon an upstream stimulus it transduces activating signals to several cellular signalling pathways, including the mitogen-activated ...

Jan 13, 2025 · In this review, we aim to summarize current knowledge on KRAS-related metabolic alterations in cancer cells and explore the prevalence and significance of KRAS mutation in shaping the tumor microenvironment and influencing …