Homepage | Journal of Neurology, Neurosurgery and Psychiatry …
3 days ago · Journal of Neurology, Neurosurgery and Psychiatry is a Plan S compliant Transformative Journal. Journal of Neurology, Neurosurgery and Psychiatry (JNNP)'s ambition is to publish the most ground-breaking and cutting-edge research from around the world. Encompassing the entire genre of neurological sciences, our focus is on the common disorders (stroke, multiple sclerosis, Parkinson's disease ...
Differentiating lower motor neuron syndromes | Journal of …
Lower motor neuron (LMN) syndromes typically present with muscle wasting and weakness and may arise from pathology affecting the distal motor nerve up to the level of the anterior horn cell. A variety of hereditary causes are recognised, including spinal muscular atrophy, distal hereditary motor neuropathy and LMN variants of familial motor neuron disease. Recent genetic advances have resulted ...
Multidisciplinary consensus guideline for the diagnosis and …
Background We aimed to create a multidisciplinary consensus clinical guideline for best practice in the diagnosis, investigation and management of spontaneous intracranial hypotension (SIH) due to cerebrospinal fluid leak based on current evidence and consensus from a multidisciplinary specialist interest group (SIG). Methods A 29-member …
Chronic inflammatory demyelinating polyneuropathy: update on …
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated neuropathy typically characterised by symmetrical involvement, and proximal as well as distal muscle weakness (typical CIDP). However, there are several ‘atypical’ subtypes, such as multifocal acquired demyelinating sensory and motor neuropathy (Lewis-Sumner syndrome) and ‘distal acquired demyelinating ...
What causes lacunar stroke? | Journal of Neurology, Neurosurgery ...
A quarter of all ischaemic strokes (a fifth of all strokes) are lacunar type.1 Lacunar infarcts are small infarcts (2–20 mm in diameter) in the deep cerebral white matter, basal ganglia, or pons, presumed to result from the occlusion of a single small perforating artery supplying the subcortical areas of the brain.2 Although a recognised stroke subtype for …
Chronic inflammatory axonal polyneuropathy | Journal of …
Objectives Chronic inflammatory axonal polyneuropathy (CIAP) is defined on the basis of the clinical, electrophysiological and nerve biopsy findings and therapeutic responses of ‘immunotherapy responding chronic axonal polyneuropathy (IR-CAP)’. Methods The diagnosis of IR-CAP was made when all of three of the following mandatory criterion were met: (1) acquired, chronic progressive or ...
HYDROCEPHALUS AND SHUNTS: WHAT THE NEUROLOGIST …
The second most common reason for being sued for negligence in neurosurgery is a problem related to hydrocephalus management (the first being spinal surgery!). However, the good news is that the overall standard of care for patients with hydrocephalus appears to have greatly improved over the last 10 years with the advent of better facilities for investigation, new approaches to treatment, and ...
Hemispatial neglect - Journal of Neurology, Neurosurgery
The syndrome of hemispatial neglect is characterised by reduced awareness of stimuli on one side of space, even though there may be no sensory loss. Although it is extremely common, it has proven to be a challenging condition to understand, and to treat. New insights from detailed behavioural and anatomical studies in patients, as well as functional imaging in healthy individuals, have begun ...
Lacunar stroke is defined as a subcortical infarct measuring less than 20 mm in diameter, caused by occlusion of a perforator of an intracranial artery.1 In this narrative review, we aim to provide an over-view of potential lacunar stroke mechanisms and diagnostic approaches, and discuss therapeutic implications targeting the underlying mechanism.
Lacunar stroke: mechanisms and therapeutic implications
Lacunar stroke is a marker of cerebral small vessel disease and accounts for up to 25% of ischaemic stroke. In this narrative review, we provide an overview of potential lacunar stroke mechanisms and discuss therapeutic implications based on the underlying mechanism. For this paper, we reviewed the literature from important studies (randomised trials, exploratory comparative studies and case ...