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1️⃣ Myasthenia gravis (MG) Antibodies target the postsynaptic side of the neuromuscular junction. Most commonly AChR, MuSK, or LRP4 antibodies. 2️⃣ Lambert-Eaton myasthenic syndrome (LEMS) Antibodies target the presynaptic side. Most commonly P/Q-type voltage-gated calcium channel (VGCC) antibodies. 👉 Different antibodies. Different mechanism. Different clues. Education only — not medical advice.#MG #autoimmunedisease #neuro #neurology #LEMS
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Primary lateral sclerosis (PLS) is a type of motor neuron disease. A motor neuron disease affects the nerve cells in the brain that control movement. In PLS, the breakdown of nerve cells causes weakness in the muscles that control the legs, arms and tongue. Symptoms typically begin with balance trouble. People with PLS may move slowly and are clumsy. Over time, symptoms evolve to include having trouble with their hands and arms, followed by problems with chewing, swallowing and speaking. Less co
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